I was born in Edappally, Kochi to (Late) C. Varghese Kelamparambil (Rtd Headmaster) and (Late) Leelamma Varghese (Teacher). He studied at the Sacred Heart College, Thevara before commencing his career in the film and Ad film industry. He married Tessy Raphel in 1999. The couple has four children — Adithya, Amy, Annie & Anthony.

A career that started off as a young Asst Director, Sijoy has been fortunate to have worked with leading Ad film production houses of India. In 2005 he found his own production house "TVC Factory",[9][failed verification] which has now grown to secure the privilege of being one of the most trusted production houses in India and UAE. Sijoy Varghese is also an actor who has performed notable characters in Malayalam films like Bangalore Days, Avatharam, James & Alice, Aadhi & Itty Maani Made In China. And, He is the current General Secretary of Indian Adfilm Makers (IAM), Kerala Chapter.